About the Project
The project aims to identify and restore key cellular pathways that are responsible for the early manifestation of Alzheimer’s disease. The goal of the project is to manipulate these pathways in a well-established rodent model of Alzheimer’s disease with a clinically approved compound and monitor changes in disease progression at the molecular, cellular, neuronal network and behavioural levels. The project requires a good academic knowledge of molecular or cellular neuroscience and a genuine interest in understanding the mechanisms of brain disease using in vivo animal models. The PhD candidate will gain advanced skills in biochemical methods, confocal optical microscopy, EEG sleep recording and learning and memory paradigms. This PhD project will be based at the Maurice Wohl Clinical Neuroscience Institute, offering state-of-the-art laboratories, an outstanding Nikon-sponsored microscopy imaging centre (Wohl Cellular Imaging Centre), and on-site animal husbandry facilities. The Maurice Wohl hosts several labs working on mechanistic causes of dementia and is also the site chosen by the Medical Research Council (MRC), Alzheimer’s Society and Alzheimer’s Research UK for one of 7 Dementia Research Institute (DRI-UK) Centres. Numerous events on the topic of dementia research are hosted through the year and provide an intellectually stimulating and supportive environment for the PhD students.