伦敦国王学院PhD Position in T cells under pressure申请条件要求-申请方
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伦敦国王学院
PhD直招介绍
About the Project
T cells under pressure
Cytotoxic CD8 T cells (CTLs) are important players in the immune response against cancer. Once activated by antigen, they migrate into tumours, adhere to their target cells and kill them by secreting a cocktail of cytotoxic enzymes. These target tissues are often biomechanically altered and much stiffer than healthy tissues, which in the case of cancer cells has been shown to affect their ability to migrate and metastasise. Preliminary date from the lab suggests that these forces can constitute a biomechanical immune evasion strategy by inhibiting the ability of CTLs to regulate their volume, polarise, create mechanical force and kill target cells.
The student will extend this work and study the impact of tissue mechanics on CTL function by first developing in vitro hydrogel systems that match the elastic, viscoelastic and osmotic properties encountered by CTLs in healthy and tumour tissues. These assays will then be used to study the impact of tissue mechanics on the ability of CTLs to migrate, signal, form an immune synapse with target cells, generate mechanical force and eventually eliminate the cancerous target cells.
This project is at the interface of material sciences, biophysics and immunology and will be supervised by an experienced team of Robert Köchl (immunology) Eileen Gentleman (bioengineering and biomechanics)( https://www.kcl.ac.uk/people/eileen-gentleman ), Leone Rossetti (traction force microscopy, biophysics). The student will be embedded in highly supportive research environment working along a postdoctoral research assistant and other PhD students in the Köchl, Rossetti and Gentleman labs.
Research training
EPSRC-funded PhD programme with ample training opportunities within the university, and access to university/department-wide seminars by world leading scientists.
Training in mouse immunology including (harvesting, activating and culturing primary mouse T cells, as well as functional assays to analyse cell migration and cytoxicity).
Training in bioengineering and biomechanics (Generation of in vitro hydrogels to mimic the tumour microenvironment, measuring mechanical properties of hydrogels and forces generated by T cells).
High level training in cutting-edge imaging approaches, potentially including quantitative live imaging using lattice light sheet microscopy, super resolution imaging modalities.
伦敦国王学院 PhD Position in T cells under pressure项目有没有奖学金，是不是全奖Phd招生，下面我们一起看一下【大学名称】Phd的奖学金资助情况
项目资助情况
This EPSRC DLA studentship will be funded at UKRI stipend rates paid for 4 years (for 2024/2025 this is £21,237 per annum, including London allowance). The studentship will also cover fees for four years. The student will be expected to submit their thesis by the end of the 4th year and the writing up period is included within the funding period. There will be support funding for training and conference attendance. The student is expected to attend and complete required training, offered through the EPSRC Doctoral Landscape Award, e.g. Responsible Research and Innovation.
伦敦国王学院Phd申请条件和要求都有哪些？PhD Position in T cells under pressure项目是不是全奖？有没有奖学金？下面我们一起看一下伦敦国王学院申请Phd直招需要具备哪些条件和要求，以及托福、雅思语言成绩要到多少才能申请。
申请要求
MSc or equivalent degree in Physics or Biology, or related discipline, either completed or expected to be completed with at least a 2.1.
Ability to work at the interface of different disciplines, such as biomechanics, bioengineering and immunology
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招生人信息
Dr Robert Köchl
邮箱：Robert.Koechl@kcl.ac.uk
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