伯明翰大学PhD position in Development of PROTAC-based technology to inhibit inflammation申请条件要求-申请方
Organizer
University of Birmingham
Description
About the Project
Inflammation is a central driver of numerous major diseases including cardiovascular indications, with the inflammasome and neutrophil extracellular traps (NETs) playing key roles in inflammatory processes.1 This PhD project aims to develop and optimize proteolysis targeting chimera (PROTAC) molecules that can selectively degrade proteins that are critical components of these inflammatory pathways. PROTACS comprise a ligand for the protein of interest (POI) and a ubiquitin ligase binding ligand; they function by bringing the POI and ubiquitin ligase into mutual proximity resulting in conjugation of ubiquitin to the POI and ultimately its degradation by the proteasome.2
Leveraging known small-molecule ligands for our targets, you will synthesize a diverse library of PROTAC constructs by varying the E3 ligase recruiting moiety and the linker connecting the target-binding and E3-binding elements. The in vitro efficacy and selectivity of the lead PROTAC candidates in degrading their respective targets will be evaluated, followed by assessment of their anti-inflammatory effects on neutrophils (targeting both NETs and the inflammasome) and platelets (targeting the inflammasome only).
You will join a vibrant, diverse and group of researchers to gain skills and knowledge in chemical and cell biology in its broadest sense, applied to a major challenge in cardiovascular biology. You will also participate in our wider collaborative research. Specific techniques include: in silico methods, synthetic chemistry, isolating blood cells, and working with cell/tissue culture, fundamental biochemical methods, fluorescence/confocal microscopy, and cell functional assays.
The University of Birmingham
The University of Birmingham was founded in 1900 on an anti-discrimination ethos accepting men and women on an equal basis. Today, as a community of over 150 nationalities in one of the UK’s most vibrant cities, we remain committed to promoting equality, diversity and fairness irrespective of age, disability, gender, pregnancy or marital status, race, religion or belief, sexual orientation or gender identity. Equality, diversity and inclusion is fundamental to research success and is at the heart of all of our activities. We know that diversity strengthens our research community, leading to enhanced research creativity, productivity and quality, and societal and economic impact.
In both The College of Engineering and Physical Sciences, School of Chemistry and The College of Medicine and Health, Institute of Cardiovascular Sciences we keen to achieve a gender and diversity balance and welcome applicants from all backgrounds. The School of Chemistry holds an Athena SWAN Bronze Award, which recognises its work in promoting women’s careers in science, technology, engineering, mathematics and medicine (STEM) in higher education. College of Medicine and Health (former School of Medical and Dental Sciences) was awarded an Athena SWAN Silver Award in 2020.
University of Birmingham PhD position in Development of PROTAC-based technology to inhibit inflammation项目有没有奖学金，是不是全奖Phd招生，下面我们一起看一下【大学名称】Phd的奖学金资助情况
Honors
Funding on offer We offer a 3-year fully-funded programme of integrated research and skills training with cross-disciplinary supervision. This studentship includes maintenance stipend (~£19.9k in yr 1 with annual increases) and tuition fees. Support for conference attendance and research materials will be available.
University of BirminghamPhd申请条件和要求都有哪些？PhD position in Development of PROTAC-based technology to inhibit inflammation项目是不是全奖？有没有奖学金？下面我们一起看一下University of Birmingham申请Phd直招需要具备哪些条件和要求，以及托福、雅思语言成绩要到多少才能申请。
Requirements
The candidate should normally have, or expect to receive, a first or upper second (2.1) class Master’s degree (or equivalent). The interdisciplinary nature of this research means that we welcome applications from students with backgrounds in any biological, chemical, and/or physical science, who are interested in using their skills in addressing biological questions.
English language requirements: The minimum English language entry requirement for postgraduate research study is an IELTS of 6.0 overall with at least 5.5 in each component (reading, writing, listening and speaking) or equivalent (e.g., TOEFL, PTE etc.). The test must be dated within two years of the start date of the course in order to be valid.
How to register
Professor
Prof Alex Brill
Email：A.Brill@bham.ac.uk
Tel.：+44 (0) 121 415 8679
Fax：+44 (0) 121 4158817
Personal website：Click to view the person website
Lab website
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